This pediatric study of hypertonic saline therapy enrolled 321 participants aged 4 months to 60 months at 30 CF care centers across the United States and Canada. The participants inhaled either 7 percent hypertonic saline, or a 0.9 percent saline mist as a control, twice daily for 48 weeks.
Overall, the hypertonic saline was well-tolerated and side effects were minimal. However, there was no difference between the two saline groups in the rate of acute lung problems that required treatment with antibiotics (average of 2.3 cases per participant per year in each group). Hypertonic saline also did not improve other clinical measurements such as coughing, respiratory rate, height, or weight. CF can stunt the growth of children.
Read the original story http://www.nih.gov/news/health/may2012/nhlbi-21.htm which was published on 21st May 2012.